Hideo Saka, MD, PhD


Clinical Research Center
Senior Research Fellow



Cancer chemotherapyPulmonary interventions


Area of Research

Cancer chemotherapy
Malignant pleural effusions
Pulmonary intervensions


Contact Information

National Hospital Organization Nagoya Medical Center
4-1-1 Sannomaru, Naka-ku, Nagoya
Aichi 460-0001, Japan
E-mail: saka[at]med.nagoya-u.ac.jp
Phone: +81-52-951-1111 ext. 6064
FAX: +81-52-971-3334



New cancer chemotherapy development
Treatment of malignant pleural effusions
Ultra-thin, and Thin bronchoscopy for pulmonary lesions


Recent Award

2006 Ikeda Awared: Japanese Society for Respiratory Endoscopy



1980, M.D., Nagoya University School of Medicine, Nagoya, Japan
1980-1982 Resident, Aichi Cancer Center Hospital, Nagoya, Japan

Professional Experience:
1982-1987 Staff Physician, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan
1987-1988 Staff Physician, Aichi Saiseikai Hospital, Nagoya, Japan
1988-1996 Staff Physician, Nagoya University School of Medicine, Nagoya, Japan
1996-2000 Visiting Assistant Professor, Nagoya University School of Medicine, Nagoya, Japan
1998-2004 Head, Department of Respiratory Medicine, Nagoya National Hospital, Nagoya, Japan
2000-present Clinical Assistant Professor, Nagoya University School of Medicine, Nagoya, Japan
2001 Visiting Lecturer, National Cancer Institute, National Institute of Health, Bethesda, MD, USA
2002 Visiting Lecturer, Peking Union Medical College, China
2002-2004 Head, Division Clinical Trial Services, Nagoya National Hospital, Nagoya, Japan
2002 Visiting Lecturer, Guangzhou Medical College, China
2003 Visiting Lecturer, Guangzhou Medical College, China
2004-present Chair, Department of Respiratory Medicine, Department of Allergology, and Head, Clinical Trial Services, National Organization Nagoya Medical Center, Nagoya, Japan
2004 Invited Symposist, The Second Conference of Lung Cancer and Bronchoscopy, Xi’an, China
2007-present Head, Cancer Chemotherapy Unit, National Organization Nagoya Medical Center, Nagoya, Japan


Selected Publications

  1. Ultrathin Bronchoscopy with Multimodal Devices for Peripheral Pulmonary Lesions: A Randomized Trial. Oki M, Saka H, Ando M, Asano F, Kurimoto N, Morita K, Kitagawa C, Kogure Y, Miyazawa T. Am J Respir Crit Care Med. 2015 Jun 3. [Epub ahead of print]
  2. Transbronchial vs Transesophageal Needle Aspiration Using an Ultrasound Bronchoscope for the Diagnosis of Mediastinal Lesions: A Randomized Study. Oki M, Saka H, Ando M, Tsuboi R, Nakahata M, Oka S, Kogure Y, Kitagawa C. Chest. 2015 May 1;147(5):1259-66.
  3. Response to Crizotinib and Clinical Outcome in ALK-Rearranged Pulmonary Pleomorphic Carcinoma. Murakami Y, Saka H, Oki M. J Thorac Oncol. 2015 May;10(5):e28-9.
  4. Ultra-Sensitive Detection of the Pretreatment EGFR T790M Mutation in Non-Small Cell Lung Cancer Patients with an EGFR-Activating Mutation Using Droplet Digital PCR. Watanabe M, Kawaguchi T, Isa SI, Ando M, Tamiya A, Kubo A, Saka H, Takeo S, Adachi H, Tagawa T, Kakegawa S, Yamashita M, Kataoka K, Ichinose Y, Takeuchi Y, Sakamoto K, Matsumura A, Koh Y. Clin Cancer Res. 2015 Apr 16. [Epub ahead of print]
  5. The role of smoking status on the progression-free survival of non-small cell lung cancer patients harboring activating epidermal growth factor receptor (EGFR) mutations receiving first-line EGFR tyrosine kinase inhibitor versus platinum doublet chemotherapy: a meta-analysis of prospective randomized trials. Hasegawa Y, Ando M, Maemondo M, Yamamoto S, Isa S, Saka H, Kubo A, Kawaguchi T, Takada M, Rosell R, Kurata T, Ou SH. Oncologist. 2015 Mar;20(3):307-15.
  6. Randomized phase III trial comparing weekly docetaxel plus cisplatin versus docetaxel monotherapy every 3 weeks in elderly patients with advanced non-small-cell lung cancer: the intergroup trial JCOG0803/WJOG4307L. Abe T, Takeda K, Ohe Y, Kudoh S, Ichinose Y, Okamoto H, Yamamoto N, Yoshioka H, Minato K, Sawa T, Iwamoto Y, Saka H, Mizusawa J, Shibata T, Nakamura S, Ando M, Yokoyama A, Nakagawa K, Saijo N, Tamura T. J Clin Oncol. 2015 Feb 20;33(6):575-81.
  7. Feasibility and accuracy of molecular testing in specimens obtained with small biopsy forceps: comparison with the results of surgical specimens. Oki M, Yatabe Y, Saka H, Kitagawa C, Kogure Y, Ichihara S, Moritani S. Respiration. 2015;89(3):235-42.
  8. Phase II study of erlotinib for previously treated patients with EGFR wild-type non-small-cell lung cancer, following EGFR mutation status reevaluation with the Scorpion Amplified Refractory Mutation System. Morise M, Taniguchi H, Saka H, Shindoh J, Suzuki R, Kojima E, Hase T, Ando M, Kondo M, Saito H, Hasegawa Y. Mol Clin Oncol. 2014 Nov;2(6):991-996.
  9. Current status and future perspectives of cooperative study groups for lung cancer in Japan. Kawano Y, Okamoto I, Fukuda H, Ohe Y, Nakamura S, Nakagawa K, Hotta K, Kiura K, Takiguchi Y, Saka H, Okamoto H, Takayama K, Semba H, Kobayashi K, Kenmotsu H, Tsuboi M, Yamamoto N, Nukiwa T, Nakanishi Y. Respir Investig. 2014 Nov;52(6):339-47.
  10. Endoscopic ultrasound-guided fine needle aspiration and endobronchial ultrasound-guided transbronchial needle aspiration: Are two better than one in mediastinal staging of non-small cell lung cancer? Oki M, Saka H, Ando M, Kitagawa C, Kogure Y, Seki Y. J Thorac Cardiovasc Surg. 2014 Oct;148(4):1169-77.
  11. Varenicline is more effective in attenuating weight gain than nicotine patch 12 months after the end of smoking cessation therapy: an observational study in Japan. Taniguchi C, Tanaka H, Nakamura N, Saka H, Oze I, Ito H, Tachibana K, Tokoro A, Nozaki Y, Nakamichi N, Sakakibara H. Nicotine Tob Res. 2014 Jul;16(7):1026-9.
  12. Randomized phase III trial of erlotinib versus docetaxel as second- or third-line therapy in patients with advanced non-small-cell lung cancer: Docetaxel and Erlotinib Lung Cancer Trial (DELTA). Kawaguchi T, Ando M, Asami K, Okano Y, Fukuda M, Nakagawa H, Ibata H, Kozuki T, Endo T, Tamura A, Kamimura M, Sakamoto K, Yoshimi M, Soejima Y, Tomizawa Y, Isa S, Takada M, Saka H, Kubo A. J Clin Oncol. 2014 Jun 20;32(18):1902-8.
  13. Cefepime monotherapy for febrile neutropenia in patients with lung cancer. Saito H, Takahashi K, Okuno M, Saka H, Imaizumi K, Hasegawa Y, Tanikawa Y, Yamamoto M, Taniguchi H, Shindoh J, Suzuki R, Shimokata K; Central Japan Lung Study Group. J Infect Chemother. 2014 Jun;20(6):365-9.
  14. Endobronchial ultrasound-guided transbronchial needle aspiration in the diagnosis of small cell lung cancer. Murakami Y, Oki M, Saka H, Kitagawa C, Kogure Y, Ryuge M, Tsuboi R, Oka S, Nakahata M, Funahashi Y, Hori K, Ise Y, Ichihara S, Moritani S. Respir Investig. 2014 May;52(3):173-8.

Complete list of all publications.

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